Patent · US Active

Permanent gene correction by means of nucleotide-modified messenger RNA

US11332726B2 · kind B2 · utility

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27Claims

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Assignees

Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet · DE
HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH FÜR DAS HELMHOLTZ-INSTITUT FÜR PHARMAZEUTISCHE FORSCHUNG SAARLAND (HIPS) · DE

Inventors

Michael Kormann · Tübingen, DE
Lauren Mays Weddle · Newport, US
Claus-Michael Lehr · Sulzbach/Saar, DE
Brigitta LORETZ · Neuhaus, DE
Emad Malaeksefat · Heidelberg, DE

Key dates

Filing date	Apr 30, 2019
Grant date	May 17, 2022
Priority date	—
Expiry date	Apr 30, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3519
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.