Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector
US11332727B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Mar 13, 2018 |
| Grant date | May 17, 2022 |
| Priority date | — |
| Expiry date | Aug 24, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods of avoiding an immune response in a subject being administered a regimen requiring Cas9 in order to optimize and broaden the application of CRIPSR based therapeutics comprising administering immune orthogonal Cas9. Also described herein are methods to modify a Cas9 protein by swapping highly immunogenic peptides or amino acids with less immunogenic counterparts. These methods are particularly useful to enable the application of Cas9 arsenal for repeat treatments. Further provided are Cas9 proteins modified to reduce immunogenicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.