Lipid particle formulations for delivery of RNA and water-soluble therapeutically effective compounds to a target cell

US11337922B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Hossam Hefesha · Wiesbaden, DE
• Ugur Sahin · Mainz, DE
• Heinrich Haas · Mainz, DE
• Sebastian Kreiter · Mainz, DE
• Yves Hüsemann · Wiesbaden, DE
• Mustafa Diken · Mainz, DE
• Kerstin Walzer · Seeheim-Jugenheim, DE

Key dates

• Filing date: May 25, 2021
• Grant date: May 24, 2022
• Expiry date: May 25, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to lipid particles comprising at least one cationic lipid, at least one water-soluble therapeutically effective compound and RNA. Further, the present invention relates to a pharmaceutical composition comprising such particles. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the particles.