Process for preparing elagolix sodium and intermediates thereof
US11339131B2 · kind B2 · utility
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22Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 17, 2020 |
| Grant date | May 24, 2022 |
| Priority date | — |
| Expiry date | Sep 17, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides improved processes for the preparation of elagolix and intermediates thereof. The intermediate of formula VII is achieved by a coupling reaction of a compound of formula V and a N-benzylidene protected compound of formula IV: The present invention is suitable for a large-scale production, avoiding the use of potential genotoxic substances and can be performed under mild conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.