Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors

US11339168B2 · kind B2 · utility

Assignee

• Kronos Bio, Inc. · US

Inventors

• Patricia Andres · West Lafayette, US
• Peter Fung · Newport, US
• Pierre Giguere · Ste. Anne, CA
• Chiajen Lai · Livermore, US
• Craig Stewart · Grafton, GB
• Jing Teng · West Lafayette, US
• Duong Tran · Edmonton, CA
• Iva Trantcheva · Sonoma, US
• Brian Yarmuch · Sherwood Park, CA

Key dates

• Filing date: Feb 20, 2020
• Grant date: May 24, 2022
• Expiry date: Mar 2, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized:Also provided are processes of making the solid forms and methods of use thereof.