Preparation for natural product trabectedin
US11339179B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Dec 11, 2018 |
| Grant date | May 24, 2022 |
| Priority date | — |
| Expiry date | Dec 11, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.