CDP protein secretion inhibitors

US11339193B2 · kind B2 · utility

Assignees

• KEZAR LIFE SCIENCES, INC. · US
• The Regents of the University of California · US

Inventors

• Dustin McMinn · Pacifica, US
• John William Taunton, Jr. · San Francisco, US
• Phillip Patrick Sharp · Elmore, AU

Key dates

• Filing date: Mar 29, 2019
• Grant date: May 24, 2022
• Expiry date: Mar 29, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g., for the treatment of cancer, arthritis, and/or inflammation.