Construction of chimeric antigen receptor targeting CD20 antigen and activity identification of engineered T cells thereof

US11339200B2 · kind B2 · utility

Assignee

• CELLULAR BIOMEDICINE GROUP HK LIMITED · CN

Inventors

• Yihong Yao · Boyds, US
• Jiaqi Huang · Rockville, US
• Shigui ZHU · Hong Kong, CN
• Wei Zhu · Shanghai, CN
• Xin Yao · Beijing, CN
• Zhiyuan Li · Nanhu, CN
• Li Zhang · Miaocheng, CN
• Lin Zhu · Lexington, US
• Anyun MA · Hong Kong, CN
• Yutian WEI · Shanghai, CN
• Yanfeng Li · Beijing, CN
• Qingxia Wang · Shanghai, CN
• Jiaping HE · Hong Kong, CN

Key dates

• Filing date: Jun 21, 2021
• Grant date: May 24, 2022
• Expiry date: Jun 21, 2041

Classification

• Technology area (CPC —): General

Abstract

Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.