Screening method of anticancer agent focused on function of HP1 and evaluation system
US11340215B2 · kind B2 · utility
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3Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 27, 2017 |
| Grant date | May 24, 2022 |
| Priority date | — |
| Expiry date | Jun 18, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1α, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.