Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups

US11344635B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Janet R. Morrow · Williamsville, US
• Zuiru Lin · Williamsville, US
• Didar ASIK · Buffalo, US
• Eric M. SNYDER · Williamsville, US
• Elizabeth A. KRAS · Amherst, US

Key dates

• Filing date: Nov 18, 2019
• Grant date: May 31, 2022
• Expiry date: Nov 18, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S-substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods.