Process for the preparation of (S)-Netarsudil,its salts and polymorphs

US11345664B2 · kind B2 · utility

Assignee

• Micro Labs Ltd. · IN

Inventors

• Punit Tripathi · Savanuru, IN
• Golla Maghava · Savanuru, IN
• Brijesh Kumar · Barwala, IN
• Peyalla Divya · Savanuru, IN
• Lalit Kumar · Noida, IN
• Thaslim Basha · Savanuru, IN
• Arun Kumar Awasthi · Savanuru, IN
• Pramod Kumar · Waterloo, CA

Key dates

• Filing date: Jun 26, 2020
• Grant date: May 31, 2022
• Expiry date: Nov 13, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of (S)-Netarsudil or its pharmaceutically acceptable salts using novel intermediates. The present invention further provides novel salts, novel intermediates and novel polymorphic forms of the (S)-Netarsudil salts and process for the preparation of the same.