Atropisomerism for increased kinase inhibitor selectivity
US11345707B2 · kind B2 · utility
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5References
19Claims
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Key dates
| Filing date | Dec 18, 2019 |
| Grant date | May 31, 2022 |
| Priority date | — |
| Expiry date | Feb 13, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.