TGR5 modulators and methods of use thereof

US11345721B2 · kind B2 · utility

Assignee

• Intercept Pharmaceuticals, Inc. · US

Inventors

• Roberto Pellicciari · Perugia, IT
• Antimo Gioiello · Perugia, IT
• Antonio Macchiarulo · Perugia, IT
• Françoise Perron-Sierra · Paris, FR
• Klaus Seedorf · Hamburg, DE

Key dates

• Filing date: Sep 2, 2020
• Grant date: May 31, 2022
• Expiry date: Sep 2, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/0005
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.