Patent · US Active

Chimeric T cell

US11345734B2 · kind B2 · utility

1Cited by

2References

5Claims

0Family size

Assignee

AUTOLUS LIMITED · GB

Inventors

Martin Pulé · London, GB
Shaun Cordoba · London, GB
Simon Thomas · London, GB
Khai Kong · London, GB

Key dates

Filing date	May 31, 2016
Grant date	May 31, 2022
Priority date	—
Expiry date	May 31, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following: (i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain; (ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain; (iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.