Esterified selenium polysaccharide and preparation method and use therefor
US11345761B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 16, 2018 |
| Grant date | May 31, 2022 |
| Priority date | — |
| Expiry date | Oct 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A preparation method for an esterified selenium polysaccharide includes the steps of: adding O═SeCl2 dropwise to a triethylamine-containing D-galactose allyl glucoside solution and reacting at room temperature to obtain 3,4-oxo-cyclo selenite galactose allyl glucoside; mixing NaHCO3 into a polysaccharide solution, adding acryloyl chloride dropwise to the polysaccharide solution and maintaining a temperature of a reaction solution to not exceed 40° C. during a dropwise addition to obtain acrylated polysaccharide; and performing a displacement reaction of the acrylated polysaccharide with the 3,4-oxo-cyclo selenite galactose allyl glucoside under an action of a Ru catalyst to obtain the esterified selenium polysaccharide. The esterified selenium polysaccharide prepared by the preparation method improves an immunity of a tested organism by increasing a selenium content in blood.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.