Patent · US Active

Method for preparing (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound

US11345941B2 · kind B2 · utility

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Assignee

FUDAN UNIVERSITY · CN

Inventors

Fener CHEN · Shanghai, CN
Zedu Huang · Shanghai, CN
Zhining Li · Shanghai, CN
Jiaqi Wang · Lo Wu, CN

Key dates

Filing date	Feb 29, 2020
Grant date	May 31, 2022
Priority date	—
Expiry date	Jul 24, 2040

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This application relates to biological pharmacy and biochemical engineering, and more particularly to a method of preparing a (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound. This method includes: subjecting a 1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline raceme as a substrate to selective oxidation in the presence of a monoamine oxidase and the non-selective reduction to prepare the (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound, where the monoamine oxidase has an amino acid sequence as shown in SEQ ID NO: 1 or an amino acid sequence having an identity of more than 80% with SEQ ID NO: 1. The kinetic resolution is carried out in the presence of the monoamine oxidase as a catalyst and a reductant, and the resulting product has a high chiral purity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.