Lysosomal targeting peptides and uses thereof
US11351231B2 · kind B2 · utility
2Cited by
76References
7Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 24, 2017 |
| Grant date | Jun 7, 2022 |
| Priority date | — |
| Expiry date | Jul 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.