Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
US11352354B2 · kind B2 · utility
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Key dates
| Filing date | Aug 3, 2018 |
| Grant date | Jun 7, 2022 |
| Priority date | — |
| Expiry date | Aug 3, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.