Inhibitors of plasma kallikrein and uses thereof

US11352356B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Nikolaos Papaioannou · Newton, US
• Sarah Jocelyn Fink · Arlington, US
• Thomas Miller · Brookline, US
• Gerald W. Shipps, Jr. · Stoneham, US
• Jeremy Travins · Southborough, US
• David Edward Ehmann · Lexington, US
• Alastair Rae · Saffron Walden, GB
• John Mark Ellard · Buntingford, GB

Key dates

• Filing date: Jun 22, 2020
• Grant date: Jun 7, 2022
• Expiry date: Jun 22, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.