Nano-scale delivery device and uses thereof

US11357830B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• TROGENEX, INC. · US

Inventors

• Sadik C. Esener · Solana Beach, US
• Negin Mokhtari · San Diego, US
• Mukanth Vaidyanathan · San Diego, US
• Ya-San Yeh · San Diego, US
• Ajay Sapre · Village of La Jolla, US
• Bartu Ahiska · Guildford, GB

Key dates

• Filing date: Mar 3, 2017
• Grant date: Jun 14, 2022
• Expiry date: Mar 3, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a delivery device for delivering a payload, including a biological, chemical or biochemical substance, to a subject. The delivery device has a nanoparticle loaded with the payload, and porous coating structure over the loaded nanoparticle to prevent the payload from escaping the delivery device, while also preserving the activity of the payload and increasing effective utilization of the payload. Also disclosed is a delivery device for delivering a payload, including a natural virus, recombinant virus, or engineered virus. Also disclosed is a delivery device that has a liposome loaded with the payload and a biocompatible surface coating over the loaded liposome. Also disclosed are methods of fabricating the delivery devices and methods of using the delivery devices in treating health conditions, such as cancer, or in diagnostic applications.