Systems and methods for determining cardiac performance

US11357968B2 · kind B2 · utility

Assignees

• ABIOMED, INC. · US
• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Ahmad El Katerji · Danvers, US
• Qing Tan · Danvers, US
• Christian Moyer · Danvers, US
• Alexander Ship · Needham, US
• Sonya Sanat Bhavsar · Danvers, US
• Noam Josephy · Danvers, US
• Elazer R. Edelman · Brookline, US
• Brian Chang · Boston, US
• Steven Keller · Stanford, US

Key dates

• Filing date: Jun 19, 2019
• Grant date: Jun 14, 2022
• Expiry date: Sep 4, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H40/67
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.