Method for preparing elagolix intermediate and composition thereof

US11365178B2 · kind B2 · utility

Assignees

• ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. · CN
• Shanghai Syncores Technologies Inc. Ltd. · CN

Inventors

• Hu Su · Shanghai, CN
• Xiaowen Guo · Shanghai, CN
• Yukun Liang · Shanghai, CN
• Kaiqiang Shi · Shanghai, CN
• Jintao Yang · Shanghai, CN
• Kang He · Shanghai, CN
• Anping Tao · Shanghai, CN
• Luning Huang · Shanghai, CN
• Jianguo An · Shanghai, CN
• Xi Chen · Beijing, CN
• Hong Gu · Dongguan, CN

Key dates

• Filing date: Dec 25, 2018
• Grant date: Jun 21, 2022
• Expiry date: Feb 13, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.