Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy

US11365236B2 · kind B2 · utility

Assignees

• Nkarta, Inc. · US
• NATIONAL UNIVERSITY OF SINGAPORE · SG

Inventors

• Jun Hao Leong · Singapore, SG
• Noriko Shimasaki · Singapore, SG
• See Voon Seow · Singapore, SG
• Dario Campana · Singapore, SG
• James Barnaby Trager · Albany, US
• Alexandra Leida Liana Lazetic · San Jose, US
• Chao Guo · San Francisco, US
• Luxuan Guo Buren · San Francisco, US
• Shyam Sashikant Masrani · London, GB

Key dates

• Filing date: Mar 27, 2018
• Grant date: Jun 21, 2022
• Expiry date: Mar 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/10043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.