Xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor

US11365293B2 · kind B2 · utility

Assignee

• South China University of Technology · CN

Inventors

• Junli Ren · 流花街道, CN
• Weiqing Kong · Nanjing, CN
• Runcang Sun · Beijing, CN
• Danyang Huang · 流花街道, CN
• Guibin Xu · 流花街道, CN

Key dates

• Filing date: Dec 14, 2016
• Grant date: Jun 21, 2022
• Expiry date: Oct 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K2003/287
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention belongs to the technical field of composite materials, and discloses a xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor. The method comprises (1) adding graphite oxide powder into deionized water, ultrasonically dispersing to obtain a GO aqueous dispersion; (2) adding xylan into deionized water, heating and stirring to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO aqueous dispersion, and stirring and dispersing uniformly under an ice-bath condition, then adding an initiator, a crosslinking agent and an accelerator, stirring and mixing uniformly to obtain a mixed solution; and 4) drying and reacting the mixed solution (in the step (3) to obtain a xylan-based dual network nanocomposite hydrogel. The composite hydrogel obtained by this invention has high mechanical property, is biodegradable and biocompatible, and can be used in the field of biomedicine, such as tissue engineering, drug sustained release, cell culture scaffold and cartilage tissue, etc.