Cellular behaviour monitoring device and method for monitoring changes in cellular behaviour
US11365386B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 2019 |
| Grant date | Jun 21, 2022 |
| Priority date | — |
| Expiry date | May 24, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0829
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
There is described a cellular behaviour monitoring device for monitoring changes in behaviour of cells contained in a sample. The device generally has a well plate with a sample receiving well recessed therein. A filter membrane extends across the well plate and hermetically covers the sample receiving well. The filter membrane has nutrient-permeable and cell-impermeable pores extending through the filter membrane. The device has an electrode layer extending across the filter membrane. The electrode layer has a substrate and behaviour monitoring electrodes spaced-apart from one another in a region of the substrate, with the region being aligned with the sample receiving well. The electrode layer has nutrient-permeable apertures distributed across the region, with at least some of pores are aligned with at least some of the apertures to allow fluid communication therebetween, and nutrient exchange between the sample receiving well and a surrounding environment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.