Beta-lactamase variants
US11365403B2 · kind B2 · utility
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2References
16Claims
0Family size
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Key dates
| Filing date | Oct 24, 2018 |
| Grant date | Jun 21, 2022 |
| Priority date | — |
| Expiry date | Nov 4, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.