Patent · US Active

Picoliter droplet sample processing and deposition for mass spectrometry

US11366122B2 · kind B2 · utility

1Cited by

1References

20Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Noel S. Ha · Los Angeles, US
Markus de Raad · Berkeley, US
Trent R. Northen · Walnut Creek, US

Key dates

Filing date	Oct 4, 2020
Grant date	Jun 21, 2022
Priority date	—
Expiry date	Oct 4, 2040

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01L9/527
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Disclosed herein include systems, devices, and methods for droplet deposition for mass spectrometry. In some embodiments, a microfluidic device comprising wells is reversibly sealed to a mass spectrometry surface and used to deposit contents of droplets (e.g., enzymes and substrates), or products thereof, onto the mass spectrometry surface. The contents of droplets can be analyzed by laser desorption/ionization to, for example, identify a substrate of an enzyme or an enzyme capable of catalyzing a substrate to a product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.