Long-acting prodrugs of rasagiline, preparing methods and uses thereof

US11369583B2 · kind B2 · utility

Assignee

• GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. · CN

Inventors

• Jiancun Zhang · Dongguan, CN
• Deyao Li · 流花街道, CN
• Yiqian ZHOU · 流花街道, CN
• Yiwu Wu · 流花街道, CN

Key dates

• Filing date: Aug 27, 2018
• Grant date: Jun 28, 2022
• Expiry date: Nov 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C271/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a long-acting prodrug of Rasagiline, which has application in the treatment of Central Nervous System diseases such as Parkinson's disease, preparation method and use thereof. The long-acting prodrug of Rasagiline has a structure of formula (I), wherein T is absent, or T is selected from each of R1 and R2 is independently selected from H, D, and alkyl; W is absent, or W is selected from (CH2)n, wherein n is an integer selected from 1 to 15; X is absent, or X is selected from (CH2)m, wherein m is an integer selected from 1 to 10; Y is absent, or Y is selected from —C(═O)NH—, —NHC(═O)—; R3 is selected from substituted or unsubstituted C1-C30 alkyl, substituted or unsubstituted C2-C30 alkenyl, substituted or unsubstituted C2-C30 alkynyl, substituted or unsubstituted C3-C30 cycloalkyl, cholane aliphatic group, —R3a—C(═O)O—R3b, —R3a—OC(═O)—R3b, —R3a—C(═O)NH—R3b, —R3a—NHC(═O)—R3b, —R3a—S(═O)1-2O—R3b and —R3a—OS(═O)1-2—R3b.