Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss

US11369607B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• Massachusetts Institute of Technology · US

Inventors

• Jeffrey M. Karp · Brookline, US
• Robert S. Langer · Newton, US
• Xiaolei Yin · Quincy, US
• Nitin Joshi · Bhangrola, IN

Key dates

• Filing date: Jan 24, 2020
• Grant date: Jun 28, 2022
• Expiry date: Jan 24, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/999
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.