Collagenase clostridium histolyticum for treatment of bladder dysfunction
US11369667B2 · kind B2 · utility
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Key dates
| Filing date | Nov 1, 2021 |
| Grant date | Jun 28, 2022 |
| Priority date | — |
| Expiry date | Nov 1, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P13/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Collagenase Clostridium histolyticum (EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal and submucosal collagen to treat various conditions such as bladder dysfunction, esophageal stenosis, benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.
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