Photocleavable nitroindoline-based crosslinkers

US11370757B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Katja Michael · El Paso, US
• Chunqlang Li · El Paso, US
• Thomas Boland · El Paso, US
• Hector P. Del Castillo · El Paso, US
• Binata Joddar · El Paso, US
• Alfredo Ornelas Sanchez · El Paso, US
• Javier Hernandez Ortega · El Paso, US
• Irodiel Vinales Lozano · El Paso, US
• Philip T. Baily · El Paso, US

Key dates

• Filing date: Oct 19, 2020
• Grant date: Jun 28, 2022
• Expiry date: Oct 19, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.