Patent · US Active

Process for preparing sulfonamide compounds

US11370807B2 · kind B2 · utility

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11Claims

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Assignees

ASCENTAGE PHARMA (SUZHOU) CO., LTD. · CN
ASCENTAGE PHARMA GROUP CORP LIMITED · CN

Inventors

Ming Guo · Suzhou, CN
Jianfeng Wen · Suzhou, CN
Huirong Lu · Suzhou, CN
Jianpeng Feng · Suzhou, CN
Jing Zhang · Wantage, US
Ming JIN · Suzhou, CN
Qianlei Cao · Suzhou, CN

Key dates

Filing date	Jan 3, 2020
Grant date	Jun 28, 2022
Priority date	—
Expiry date	Jan 3, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/07
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.