Patent · US Active

Subtilase cytotoxin B subunit mutant

US11371033B2 · kind B2 · utility

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1References

16Claims

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Assignees

GRIFFITH UNIVERSITY · AU
University of Adelaide · AU

Inventors

Michael Paul Jennings · Forsayth, AU
Christopher Day · Gold Coast, AU
Adrienne Webster Paton · Jerramungup, AU
James Cleland Paton · Jerramungup, AU

Key dates

Filing date	Nov 9, 2017
Grant date	Jun 28, 2022
Priority date	—
Expiry date	Jul 9, 2038

Classification

Technology area (CPC G)Physics
CPC primaryG01N2400/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having α2-3-linked N-glycolylneuraminic acid and glycans having α2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having α2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having α2-3-linked N-glycolylneuraminic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.