Flow cell with integrated manifold

US11376584B2 · kind B2 · utility

Assignee

• Illumina, Inc. · US

Inventors

• Sz-Chin Steven Lin · San Jose, US
• Jay Kendall Taylor · Ottawa, CA
• Minsoung Rhee · San Diego, US
• Jennifer Foley · San Diego, US
• Wesley A. Cox-Muranami · San Diego, US
• Cyril Delattre · San Diego, US
• Tarun Khurana · San Diego, US
• Paul Crivelli · San Diego, US

Key dates

• Filing date: May 1, 2019
• Grant date: Jul 5, 2022
• Expiry date: Apr 8, 2040

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/08
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.