Modulators of stimulator of interferon genes (STING)

US11377440B2 · kind B2 · utility

Assignee

• GlaxoSmithKline Intellectual Property Development Limited · GB

Inventors

• David T. FOSBENNER · Collegeville, US
• Todd L. Graybill · Pottstown, US
• Jianxing Kang · Collegeville, US
• Bryan Wayne King · Blue Bell, US
• Yunfeng Lan · Collegeville, US
• Lara Kathryn Leister · Collegeville, US
• Mukesh Mahajan · Collegeville, US
• John F. Mehlmann · Collegeville, US
• Angel Morales-Ramos · Blue Bell, US
• George Scott Pesiridis · Collegeville, US
• Joshi M. Ramanjulu · Collegeville, US
• Joseph J. Romano · Collegeville, US
• Stuart Paul Romeril · Collegeville, US
• Mark Schulz · Skippack, US
• Huiqiang Zhou · Durham, US
• Junya Qu · Collegeville, US

Key dates

• Filing date: Oct 4, 2018
• Grant date: Jul 5, 2022
• Expiry date: Oct 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds having the formula: (I) wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, R17, Rx, and Ry are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.