Pyridopyrimidine compounds acting as mTORC 1/2 dual inhibitors

US11377444B2 · kind B2 · utility

Assignee

• Medshine Discovery Inc. · CN

Inventors

• Kevin X. Chen · Edison, US
• Zhaoguo Chen · Shanghai, CN
• Li Zhang · New Milford, US
• Yanxin YU · Shanghai, CN
• Kai ZHOU · Shanghai, CN
• Boyu HU · Lianyungang, CN
• Xiaofei Wang · Shanghai, CN
• Guoping HU · Shanghai, CN
• Jian Li · Shanghai, CN
• Shuhui CHEN · Shanghai, CN

Key dates

• Filing date: Nov 2, 2018
• Grant date: Jul 5, 2022
• Expiry date: Dec 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors.