Compositions and methods for treating cancer

US11377451B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• David A. Nathanson · Los Angeles, US
• Michael E. Jung · Los Angeles, US
• Jonathan Tsang · Los Angeles, US
• Lorenz Urner · Los Angeles, US
• Peter M. Clark · Los Angeles, US
• Timothy F. Cloughesy · Calabasas, US
• Gyudong Kim · Seoul, KR

Key dates

• Filing date: Sep 14, 2021
• Grant date: Jul 5, 2022
• Expiry date: Sep 14, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compounds, compositions and methods for treating cancer, including compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating cancer in the brain, including glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating cancers such as glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.