Patent · US Active

Ribonucleic acid purification

US11377470B2 · kind B2 · utility

2Cited by

52References

17Claims

0Family size

Assignee

ModernaTX, Inc. · US

Inventors

William Issa · Dedham, US
John Grant Aunins · Cambridge, US
Stephane Bancel · Cambridge, US

Key dates

Filing date	Mar 13, 2014
Grant date	Jul 5, 2022
Priority date	—
Expiry date	Mar 13, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6806
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2′deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.