Maleate salt of benzothiophene compound, crystalline form thereof, and use thereof

US11384073B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. · CN
• TOPHARMAN SHANGHAI CO., LTD. · CN

Inventors

• Jingshan Shen · Shanghai, CN
• Yang He · Sichuan, CN
• Zhen Wang · Shanghai, CN
• Jianfeng Li · Qingdao, CN
• Yongjian Liu · Chesterfield, US
• Jin Suo · Shanghai, CN
• Guanghui Tian · 安丰镇, CN
• Weiming Chen · Shanghai, CN
• Feipu YANG · Shanghai, CN
• Yu Wang · Xi'an, CN
• Xiangrui Jiang · Shanghai, CN
• Rongxia Zhang · Shanghai, CN
• Hualiang Jiang · Shanghai, CN

Key dates

• Filing date: Dec 18, 2020
• Grant date: Jul 12, 2022
• Expiry date: Dec 18, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation.