Tetrahydroisoquinoline derivative, preparation method therefor and use thereof

US11384097B2 · kind B2 · utility

Assignee

• Zhejiang Hisun Pharmaceutical Co., Ltd. · CN

Inventors

• Yanghui Guo · Zhejiang, CN
• Xiangui Huang · Zhejiang, CN
• Weiwei Liao · Zhejiang, CN
• Lichen MENG · Zhejiang, CN
• Taishan Hu · Shanghai, CN
• Lei Chen · Singapore, SG
• Guoping JIANG · Zhejiang, CN

Key dates

• Filing date: Jun 18, 2019
• Grant date: Jul 12, 2022
• Expiry date: Jun 22, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.