Catechol group modified biomacromolecular scaffold material and preparation method thereof

US11384162B2 · kind B2 · utility

Assignee

• Jiangnan University · CN

Inventors

• Dongjian Shi · 安丰镇, CN
• Jiali Shen · 安丰镇, CN
• Zhuying Zhang · 安丰镇, CN
• Chuanhao Cao · 安丰镇, CN
• Qian Zhao · Beijing, CN
• Xiaojie Li · Xi'an, CN
• Mingqing Chen · Wuxi, CN

Key dates

• Filing date: Aug 31, 2017
• Grant date: Jul 12, 2022
• Expiry date: Aug 28, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention discloses a preparation method of a catechol group modified biomacromolecular scaffold material, comprising: grafting a catechol-containing compound by amidation to obtain modified biomacromolecules; then, allowing dopamine to perform oxidized self-polymerization in a weakly alkaline buffer solution to form polydopamine (PDA) particles with a uniform particle size; next, forming a scaffold which has three cross-linking structures, namely modified biomacromolecules, modified biomacromolecules/PDA, and biomacromolecules/PDA, through interaction between catechol groups, interaction between catechol groups and PDA particles, and interaction between macromolecules and PDA particles in the modified macromolecules respectively; and cross-linking the scaffold with calcium ions, adipic dihydrazide or genipin to further adjust the degree of cross-linking and porosity of the scaffold. The prepared scaffold material has excellent biocompatibility and biodegradability, can promote cell adhesion, and has a wide application prospect in the field of tissue repair and regeneration.