Non-invasive diagnostic biomarker for pancreatic islet populations

US11389106B2 · kind B2 · utility

Assignees

• University of Florida Research Foundation, INC. · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Eric C. Porges · Gainesville, US
• Damon Lamb · Gainesville, US
• Martha Campbell Thompson · Micanopy, US
• Richard Edden · Baltimore, US

Key dates

• Filing date: Oct 17, 2018
• Grant date: Jul 19, 2022
• Expiry date: Oct 17, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/4616
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aspects of the disclosure relate to systems and methods for obtaining and interpreting magnetic resonance spectroscopy (MRS) data obtained from the pancreas of a subject. In some embodiments, systems and methods of the disclosure relate to analyzing MRS spectra of metabolites, for example y-Aminobutyric acid (GABA), to assess pancreatic islet density and function in a subject. In some embodiments, systems and methods described by the disclosure are useful for the diagnosis and/or treatment of diseases associated with impaired pancreatic function, for example diabetes.