Methods and pharmaceutical compositions for the treatment of mast cell diseases
US11389434B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | May 17, 2018 |
| Grant date | Jul 19, 2022 |
| Priority date | — |
| Expiry date | May 25, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). These results prompt the inventors to explore the consequence of the inhibition of the HH pathway, especially the canonical pathway, on MC proliferation. They demonstrate that Hedgehog inhibitors inhibit proliferation and induces apoptosis of mast cells. Accordingly the present invention relates to a method of treating a mast cell disease in a patient in need there of comprising administering to the patient a therapeutically effective amount of a Hedgehog inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.