Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition

US11389452B2 · kind B2 · utility

Assignee

• Isofol Medical AB · SE

Inventors

• Göran Carlsson · Stenhamra, SE
• Bengt Gustavsson · Mörbylånga, SE
• Elisabeth Odin · Göteborg, SE
• Yvonne Wettergren · Göteborg, SE
• Anders Vedin · Göteborg, SE

Key dates

• Filing date: May 4, 2020
• Grant date: Jul 19, 2022
• Expiry date: May 4, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for increasing plasma dUrd levels comprising the administration of 6R-MTHF. The methods of increasing plasma dUrd increase dUrd levels compared to equimolar concentrations of LV. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF.