Patent · US Active

Modified chimeric antigen receptors and methods of use

US11390655B2 · kind B2 · utility

1Cited by

17References

6Claims

0Family size

Assignee

Kite Pharma, Inc. · US

Inventors

Stuart A. Sievers · San Fernando, US
Jed Wiltzius · Santa Monica, US

Key dates

Filing date	Nov 15, 2018
Grant date	Jul 19, 2022
Priority date	—
Expiry date	Mar 16, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N5/0638
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The disclosure provides a chimeric antigen receptor (CAR) comprising a modified hinge, transmembrane and/or intracellular domain disclosed herein. Some aspects of the disclosure relate to a polynucleotide encoding a chimeric antigen receptor (CAR) comprising the costimulatory domain disclosed herein. Other aspects of the disclosure relate to cells comprising the CAR and use in a T cell therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.