Methods of obtaining tumor-specific T cell receptors

US11390659B2 · kind B2 · utility

Assignees

• SYZ Cell Therapy Co. · CN
• HRYZ (Shenzhen) Biotech Co. · CN

Inventors

• Xiangjun Zhou · Tangxia, CN
• Yanyan Han · Lafayette, US
• Xiaoling Liang · 流花街道, CN
• Xihe Chen · Lo Wu, CN

Key dates

• Filing date: Apr 12, 2019
• Grant date: Jul 19, 2022
• Expiry date: Apr 12, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.