Nucleic acid extraction materials, systems, and methods
US11390864B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 28, 2018 |
| Grant date | Jul 19, 2022 |
| Priority date | — |
| Expiry date | Jun 28, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1013
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In the examples set forth herein, nucleic acid extraction materials are capable of selectively extracting cell free nucleic acids, including cell free DNA, directly from whole blood samples or plasma. Also included are methods of making and using the nucleic acid extraction materials. One example of a nucleic acid extraction material includes a substrate. This example of the nucleic acid extraction material also includes a polycation bonded to at least a portion of a surface of the substrate. In this example, the polycation consists of a polymer of a quaternized monomer selected from the group consisting of a quaternized 1-vinylimidazole monomer and a quaternized dimethylaminoethyl methacrylate monomer, or a copolymer of a neutral monomer and the quaternized monomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.