Preparation and storage of liposomal RNA formulations suitable for therapy

US11395799B2 · kind B2 · utility

Assignee

• BIONTECH SE · DE

Inventors

• Heinrich Haas · Mainz, DE
• Sebastian Hörner · Mainz, DE
• Isaac Hernan Esparza Borquez · Mainz, DE
• Thomas Hiller · Mainz, DE
• Ferdia Bates · Mainz, DE

Key dates

• Filing date: Oct 18, 2018
• Grant date: Jul 26, 2022
• Expiry date: Oct 18, 2038

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.