Cyclic peptide analogs of melanocortin and amanitin and methods of making such
US11396535B2 · kind B2 · utility
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Key dates
| Filing date | Feb 28, 2020 |
| Grant date | Jul 26, 2022 |
| Priority date | — |
| Expiry date | Feb 28, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.