Anti-NET compounds for treating and preventing fibrosis and for facilitating wound healing

US11400139B2 · kind B2 · utility

Assignee

• Children's Medical Center Corporation · US

Inventors

• Denisa D. Wagner · Dover, US
• Siu Ling Wong · Sha Tin, CN
• Kimberly Martinod · Boston, US
• Luise Erpenbeck · Boston, US
• Jörn Thilo WITSCH · Freiburg (Elbe), DE
• Alexander Savchenko · Boston, US

Key dates

• Filing date: Jan 19, 2016
• Grant date: Aug 2, 2022
• Expiry date: Apr 2, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/21001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.